Quthero, a start-up company based on research conducted in Dr. Milica Radisic’s lab by TOeP trainee Serena Mandla accepted into the 2018 UTEST cohort”
Quthero is developing advanced therapeutic biomaterials for tissue repair and wound healing.
Based on a molecule, Q-peptide, in a hydrogel carrier that activates regenerative mechanisms
it is effective in a single application of the peptide at a nanomol-concentration.
aim is to develop a range of regenerative therapies from topical treatments for cutaneous wounds to injectable therapies for cardiovascular diseases.
Promising opportunities for partnering in new ideas
AngioChip
AngioChip was developed based on research conducted in Dr. Milica Radisic’s lab by TOeP trainee Boyang Zhang
microfabricated scaffold with a built-in micro-channel network that can be populated with endothelial cells to mimic a 3D vascular network with exterior populations of a variety of parenchymal cells.
Engineered tissues based on AngioChip can respond to clinically relevant drugs delivered through the internal vascular system.
AngioChip is patented and licensed to TARA BIOSYSTEMS. TARA is in the process of developing this technology for commercialization.
InVADE (Intergrated Vasculature for Assessing Dynamic Events)
developed based on research conducted in Dr. Milica Radisic’s lab by TOeP trainee Boyang Zhang and Benjamin Lai
InVADE 96-well plate contains an array of miniaturized versions of AngioChip cultured in the format of a 96-well plate, allowing multiple micro-tissues of to be assayed.
Micro-tissues of different cell origin can also be connected in series to facilitate inter-organ cross-talk (ie. cancer metastasis, migration and infiltration into a secondary organ can be modeled on the InVADE 96-well plate)
The InVADE 96-well plate is patented and licensed to TARA BIOSYSTEMS. TARA is in the process of developing this technology for commercialization.
Apparatus and method for high-fidelity podocyte cultivation
This apparatus was developed based on research conducted in Dr. Milica Radisic’s lab by TOeP trainees Anastasia Korolj and Boyang Zhang
US patent has been filed for an apparatus featuring a non-planar microtopology for cultivation of cells, particularly podocytes.
a differentiation media for podocyte cultivation was defined.
Revertome
development based on research conducted in Dr. Axel Guenther’s lab by TOeP trainee Richard Cheng, in collaboration with Dr. Marc Jeschke at Sunnybrook Health Sciences Centre
a surgical instrument that delivers cells in a bioink via a compact handheld bioprinter to treat severe burns.
printhead allows sterile and consistent deposition of biological materials over large physiological surfaces
several families of patents have either been granted or filed and commercialization of the technology is being pursued with clinical collaborators at Sunnybrook Health Sciences Centre and with the Creative Destruction Lab Toronto.
P-OET-Chip was developed based on research conducted in Dr. Aaron Wheeler’s lab by TOeP trainee Shuailong Zhang
This microchip utilizes light to manipulate and sort different cells.
This microchip is easy to fabricate and may find use in applications such as cell sorting and studying cell-cell interactions in a highly controlled manner.
Filed a provisional US patent for this tool.
TissueX Technologies
Developed based on research conducted in Dr. Peter Zandstra by Mukul Tewary.
TissueX’s PEGUSYS technology enables adherent cell-based patterning of any size and shape in multiwell tissue culture plates.
PEGUSYS also supports the growth of 3D tissues including organoids.
The PEGUSYS cell patterning technology is owned by TissueX Technologies. TissueX is in the process of developing this technology for commercialization.
Revertome
